NFL Betting Missouri – How to Bet on Football Games

If you’re like me and you live for Sunday football, this guide will help you find the best NFL betting sites Missouri has to offer. Online sports betting in Missouri is now legal and live. That means there will be NFL betting in MO for the final weeks of the regular season, the playoffs, and the Super Bowl.

To get you ready, I’ve compiled a complete guide to NFL betting in Missouri. Below, you will find all you need to know about which Missouri NFL sites are available, different football bet types, NFL betting tips and strategies, how to find and interpret team odds, and other advice about betting on the NFL in MO.

Top NFL betting sites in Missouri

NFL betting is legal and live in Missouri. Below are some of the top sites for NFL betting, along with information about the types of NFL-related Missouri sports betting promos they offer.

What types of NFL bets can I place?

Missouri is now home to many first-time bettors. If that’s you (or even if you’re just a casual bettor), it helps to know the main types of wagers offered. Here’s a quick guide to the main wagers you can now place on NFL games in Missouri.

All examples in this section are from past games and are not representative of current odds. They’re used for explanation purposes only.

Moneyline

Moneyline bets are the simplest wagers you will be able to place in Missouri. Pick a winner, and your wager wins if the team you selected is victorious. In football betting, this means some odds can have big payouts, but only if the underdog in a mismatch wins. Here are a few moneyline examples from DraftKings and FanDuel.

The only difference here is a tiny tweak to FanDuel’s odds on the Ravens. That wager would be slightly more at FanDuel than at DraftKings, if successful. Keep in mind as well that less even matchups will have even wider disparities, such as FanDuel’s odds on the Bills-Saints matchup:

• Bills: -1400
• Saints: +830

By the way, those odds are expressed as American odds, which is the format used by most sites in the US. These numbers represent the payout for a winning wager. Underdogs have a positive number that indicates the potential return on a $100 bet. So here, if you place a moneyline bet on the Saints and they win, you’d win $800 for a $100 bet.

Meanwhile, favorites’ odds are negative numbers. In that case, the number represents what you’d have to wager in order to win $100, such as in this case, where a moneyline wager on the favorite Bills would have to be $1,400 just to win $100 — not such a great return! Keep in mind you can wager any amount (especially online, where the minimum wagers are low), and the payouts will be proportionate (e.g., a $14 moneyline bet on the Bills to win would pay $1).

Point spread

Point spreads are similar to moneylines, but they give fake points to the underdog team while subtracting fake points from the favored team. Once the game ends, factor in those phantom points to determine the outcome. If your wager wins, that means your team “covered the spread.”

Here’s a comparison of Ravens-Chiefs odds at FanDuel and DraftKings.

Once the final score of the game is confirmed, factor in the spread. If you bet on the Chiefs and the final score is Ravens 27, Chiefs 25, you’d add 2.5 to the Chiefs’ score for a total of 27.5. That beats 27, which means the Chiefs covered the spread to win the bet.

Conversely, you’d need to subtract 2.5 from the Ravens’ score, and they’d still need to win to cover the spread. Point spreads can be great for evening out the odds when two mismatched teams play each other.

Over/Under (Totals)

Over/unders, aka totals, are bets on the final total score of a game, regardless of who wins or loses. You wage on the over (total score above a certain threshold) or the under (total score below a certain threshold).

To calculate the total, just add the two scores of the teams together. Here’s an example from BetRivers from a game that happened early in the 2025 season:

In this example, the “line” or the threshold for scoring is 47.5. This means you’re betting on whether the total score will exceed 47.5 (over) or fall below it (under). Here are some potential outcomes and their results in an over/under bet:

• Final score: Cowboys 20, Packers 26 — total 46, under
• Final score: Cowboys 35, Packers 28 — total 63, over
• Final score: Cowboys 25, Packers 23: total 48, over

If you remember that crazy Sunday Night Football game, the actual final score was a 40-40 tie, which meant the total (80 points) went way over.

In some cases, the totals line is a whole number. If the total is the exact same as the line when the game ends, those bets are usually a push (you get your money back but no winnings).

Parlays

When parlay betting, you combine multiple individual wagers (called legs) into a single mega-wager with higher-paying odds than its parts. Sounds nice, right? It is nice, but there’s a catch. If even one leg of your parlay fails, the whole site is a bust. Here’s a parlay from BetMGM.

• Parlay legs: Colts vs. Rams over 49.5 (-110); (2) Cowboys +7 (-115); (3) Eagles moneyline (-190)
• Total odds: +444

The odds are way better combined than with each wager on its own, but one mess-up could bring it all down to a loss. Note that sites also accept same-game parlays, or SGPs, which let you combine bets from a single game into a parlay.

Player props

Player prop bets are wagers on the performance of a specific player within a game. Winning or losing isn’t the key here, as long as your player performs according to your wager. There are myriad NFL examples, including these from FanDuel.

• Patrick Mahomes Passing TDs: Over/Under 1.5 (-114/-114)
• Travis Kelce Anytime TD scorer: +120
• Lamar Jackson Over/Under 225.5 Passing Yards (-114/-114)

You’ll also find props on player rushing yards, catches, and other stats. Note that in Missouri, player props aren’t allowed for college football betting, but they are permitted for the NFL.

Futures

Technically, every bet is on something to happen in the future. But futures bets are a specific type of wager, usually on an outcome that won’t be settled today or tonight, but at some future date. In the NFL, popular futures include the AFC Championship winner, a team to make the playoffs, and the Super Bowl winner. Here are a couple of futures from early in the season at BetMGM:

• Bills to win the Super Bowl: +425
• Chiefs to win the AFC Championship: +650

Futures bets come with solid-paying odds, but that’s because you’re picking from a wide field, and it’s hard to predict that far in advance.

NFL betting strategy basics (that actually help)

Betting involves a lot of chance. There’s never a guarantee that you’ll win, so keep that in mind and play responsibly. That said, you can deploy some strategies to give yourself an edge while understanding that every wager involves taking a risk.

Beginner tips

• Don’t chase big parlays: They might be enticing, but remember that even one leg failing will send the whole thing crumbling. Parlays aren’t inherently bad; just place them sparingly.
• Shop around: Odds can differ from one site to the next. While the differences may be small, they can still have a significant impact on your payout. A moneyline of -146 at one site is better than -150, for example.
• Start simple: Moneylines, totals, and point spreads tend to be the easiest bets for beginners to understand. Use them as a way to get familiar with how everything works.

Intermediate tips

• Understand implied probability: The odds on either side of a matchup indicate the implied probability of each team winning. There are online calculators to help you find the implied probability, which you can then use to inform your bets.
• Fade the public (sometimes): lines can move due to heavy public betting activity. If you suspect a team has better chances than the odds suggest, consider fading the public and betting against the grain.
• Track injury reports and weather: Both factors can significantly impact the outcome of a game. Is a team playing in unfamiliar weather? Is a star player injured? Consider these things when placing your bets. Some sites, like FanDuel Sportsbook, even feature an AI betting chatbot that can help you make better-informed decisions.

NFL betting mistakes to avoid

• Start slow: Don’t place a ton of bets right off the bat. Start slowly when you begin to understand how sports betting works.
• Be selective about parlays: The sites love it when you bet parlays, especially ones with lots of legs and big payouts. That’s because parlays are hard to win, and more often than not, you aren’t going to be collecting that huge payday. Don’t go overboard with lots of parlays, especially when starting out, or you’ll risk running through your bankroll faster than Mahomes escaping the rush and getting another first down.
• Check your fandom: If your team isn’t great (trust me, I know the pain as a Chicago Bears fan), don’t let your rooting interest cloud your judgment.

If you are interested in learning more strategies and tips, check out our How to Bet Guide.

Is it legal to bet on the NFL in Missouri?

Yes, NFL betting is legal and live in Missouri.

The legalization includes both online and retail Missouri gambling venues. The state’s casinos and sports venues will be allowed to operate retail betting locations. Meanwhile, apps and sites started accepting NFL bets on December 1, 2025.

Anyone 21 or older and within state borders has the opportunity to place bets on the NFL. You can even do so from a mobile app at one of the best bars in KC to watch Chiefs games.

NFL sports betting in Missouri is almost here!

Whether you’re a seasoned bettor or brand new to NFL betting, Missouri offers plenty of great options. Get ready to start placing bets at DraftKings, FanDuel, and other top sites. Use this page as your guide to prepare for kickoff and get ready to wager with the best NFL betting sites in Missouri.